I’m an instant fan of Twitter Bootstrap. I know it makes my site look kind of generic, but it’s not like I was putting days and days of effort into style and uniqueness before. And it looks less crap now. I can do a little design here and there when I really try, but I’ve learned over the years that spending tons of time on “personal”, “portfolio” or “professional” sites creates a black-hole timesink that I never escape from and am never happy with.
So, Bootstrap. Now it looks less horrible, and it was super, super easy.